I have two quick questions:

1- Does in-game fatigue effect every player, or just D-linemen? We rotate D-linemen due to fatigue, but no other players. I am just wondering if everyone else sees performance drop off (just to a smaller level) as the game wears on.
2- Let's say I am running a base 4-3 defense, but pull a lineman in my nickel or dime package. Would it be better to run with DE3 ends, since there are only 3 linemen, or DE4 ends, because the game penalizes me for playing guys out of their "scheme"?

TIA