I know there is a slight out of position penalty for playing players at same position they are listed at but just the other side (example: playing a LG at RG).

My question is do I play my best player at his natural position and move the other one to the other side? Or, do I play my best player, out of position on the other side, and keep the lessor skilled one at his natural position?

Is it better to take the slight out of position penalty on my better player or the lessor player? Which arrangement would give me the best max possible for the combo?